Remco Evenepoel started the 2022 edition of Liege-Bastogne-Liege without the 2020 and 2021 winners, Primož Roglič and Tadej Pogačar, on the start list, but with Wout van Aert as the favourite for the race. After his co-leader, Julian Alaphilippe had crashed badly earlier in the race, Evenepoel dropped everyone on the second-to-last climb, Côte de La Redoute and used his elite time-trial abilities to solo away. The peloton lead for some time by Mikel Landa did not stand a chance to catch the Belgian, who won his first monument at only 22 years old.
Matej Mohorič, taking every possible risk on the Poggio descent, gaining a few valuable seconds. Unsurprisingly, the big stars did not cooperate well behind him, as Mohorič soloed to become the first Slovenian to ever win Milano-Sanremo.